Evidence Based

Fluoride’s Effect On The Pineal Gland?

Through the pineal gland’s unique features and fluoride’s toxic and reactive nature, the fluoride-pineal gland relationship was bound to fail from the start.

Making the pineal gland fluoride’s number 1 victim.

What Does The Pineal Gland Do?

The pineal gland is a tiny, pinecone shaped gland located in between the two hemispheres of the brain and outside the blood brain barrier (BBB).

picture of pineal gland location

The main function of the pineal gland is to synthesize and secrete the hormone melatonin.1

Melatonin is then used to perform three main roles:

  1. maintain the circadian rhythm (sleep-wake cycle)2
  2. regulate the onset of puberty in females3
  3. help protect the body from cell damage caused by free radicals4,5

When the pineal gland is not producing melatonin or not enough of it, the body then can not perform these vital roles.

When these vital roles are not performed, this leads to a cascading domino-like effect in the body. 

Calcification Of The Pineal Gland?

It was only until the 1990’s, a British scientist, Jennifer Luke, discovered that fluoride accumulates to strikingly high levels in the pineal gland.6

More in the pineal gland than any other soft tissue of the body.

picture of calcified pineal gland

The accumulation of fluoride forms phosphate crystals, creating a thick shell around the pineal gland called calcification.

Once the pineal gland is calcified, it causes it to become in/underactive.6

Resulting in less melatonin production.7

Why Does Fluoride Accumulate In The Pineal Gland?

The pineal gland has several characteristics unique to itself that attracts the accumulation of fluoride.

main reasons fluoride accumulates in pineal gland

Since the pineal gland’s cells require direct and unimpeded contact with blood to perform it’s functions.8 It’s located outside the blood brain barrier(BBB), directly exposing the pineal gland to fluoride circulating in your blood.

This leaves the pineal gland vulnerable and without any protection.

To make things worse, the pineal gland also holds the second richest capillary network, right after the kidney.9

Resulting in lots of contact with blood, through the tremendous amount of blood flow delivered by the connecting capillaries. 

Lastly, it does not help that the pineal gland holds the highest calcium concentration of any normal tissue in the body.3 As explained in, what is fluoride, fluoride’s negatively charged and reactive nature means it loves to react with positively charged ions in the body.

It’s favorite to react with?

You guessed it, calcium…

Making fluoride the best suited substance to damage the pineal gland.

Based on this and other evidence, the National Research Council stated in 2006, “Fluoride is likely to cause decreased melatonin production and to have other effects on normal pineal function, which in turn could contribute to a variety of effects in humans.”.10

Health Effects Of Pineal Gland Calcification?

1. Sleep-Wake Cycle Impairments

insomnia icon

When there is less melatonin produced, the first thing to take a hit is the quality of your sleep.11

You could say the production of less melatonin is the first domino, while the second is sleep.

The extent this affects your sleep depends on the extent to which your pineal gland is calcified. As the pineal gland calcifies further, poor sleep eventually turns to primary insomnia.12,13

Once your body does not have the chance to replenish itself through sleep, the likelihood of many other health effects slowly but surely increase.

With each poor sleep, you take one step closer to the next health outcome. 

2. Early Puberty

teenage girl icon

In the United States and Canada, children are reaching the age of puberty at earlier ages than ever before.14

A trend, that carries with it, serious health consequences (the next one on this list).

As evidence suggests that fluoride exposure leads to reduced melatonin levels and shortened time to puberty.3

But this isn’t breaking news.

Even the first published fluoridation safety experiment based in Newburg, New York, supported the early puberty claims. As the authors uncovered, girls living in a fluoridated community reached puberty five months earlier than girls living in a non-fluoridated community.15

3. Heightened Risk For Breast Cancer

breast cancer icon

The way early puberty is linked with breast cancer, is by being an established risk factor for breast cancer… influencing a woman’s lifetime estrogen exposure.16

Swinging back to melatonin, the powerful chemical is also known to fight and halt the spread of different types of cancer- with a unique effect on breast cancer cells. Being capable of disrupting estrogen-mediated pathways, resulting in a net reduction in estrogenic stimulation of cells.17

This means, decreasing levels of melatonin strips the body of ammunition it would have otherwise used to decrease breast carcinogenesis.

For years researchers have pointed at the inhibition of melatonin on bright artificial light.18

However, now it seems like a bigger and more preventable cause is the calcification of the pineal gland. 

4. Increased Oxidative Stress

oxidative stress icon

As discussed in, what does fluoride do to the brain, one of the several effects fluoride has on the brain is causing oxidative stress.

This is typically observed in the subjects brain with three distinct characteristics:19

  1. Fluoride exposure decreased the level of antioxidant enzymes in the brain (i.e. catalase, GSH-PX and SOD) Antioxidants enzymes play a role as a natural defense against oxidative stress in the body. 
  2. Fluoride exposure increases the level of lipid peroxidation in the brain (an indicator of oxidative stress). 
  3. These toxic effects were reduced by simultaneous treatment with antioxidant vitamins (vitamins C and E). 

Now it is probable that the increased oxidative stress observed in fluoride-treated subjects is related to fluoride’s effect on the pineal gland. 

In fact, it’s even likely as we know of melatonin’s many functions, one of its most important functions is the role it plays as a powerful antioxidant- aka ward off and reduce oxidative stress.4,5

Thus, anything that can reduce the melatonin levels in the body would therefore be expected to reduce the body’s defense against oxidative stress in the brain.

Leading to more oxidative stress. 

The problem with too much oxidative stress is that it commonly results in neurodegenerative diseases.20

5. Alzheimer’s Disease

brain icon

The link between a damaged pineal gland and Alzheimer’s is very clear.

Alzheimer’s is a neurodegenerative disease, which the development of is accompanied by changes in lifestyle factors, such as sleep disturbance.21

As mentioned, one of the main roles of the pineal gland is to secrete melatonin and directly control circadian rhythm (the thing that helps you sleep).

Furthermore, we know the pineal gland has a remarkable antioxidant property and Alzheimer’s is a disorder that is characterized by progressive degeneration of the function and structure of the central nervous system.

Now what causes degeneration (damage) to the brain?

Oxidative stress. 

Neurodegenerative disorders linked to oxidative stress

Without a fully functioning pineal gland, the inability of your body to properly recover during sleep and the lack of melatonin to fight oxidative stress in the brain is a perfect combo to Alzheimer’s disease. 

Which is exactly why, reduced pineal gland volume and pineal calcification, accompanied by cognitive decline and sleep disturbances have been observed in Alzheimer’s patients.22

Something that needs to be addressed immediately, as current research reported at present levels there are more than 47 million Alzheimer patients globally, with the number projected to triple and reach 150 million by 2050.21

How To Decalcify The Pineal Gland?

The truth about fluoride is that it’s nothing but bad news for the pineal gland.

As clearly, we would like to avoid:

  • Decreased melatonin production,
  • Erratic Circadian Rhythm, or
  • Altered reproductive function

The domino-like effect any one of the three would lead to too many health consequences.

summary of helath consequences due to fluoride-pineal gland interaction

Thankfully, the solution is simple. 

Stop putting substances that hurt the pineal gland into your body and start sending it things that will help it recover.

In fact, something so simple like drinking water from a fluoride filter could help cure the damage done to you pineal gland.

But to make this as easy as possible, I explain the entire process in my free fluoride detox guide (link to guide).

See you there.

Oh, one last thing!

If you have a few seconds, share this article with your friends and family using the sharing buttons found at the bottom of the screen. It’s greatly appreciated.

Plus you might just save their pineal gland!

  1. Kunz D, Schmitz S, Mahlberg R, Mohr A, Stoter C, Wolf KJ, Herrmann WM. A new concept for melatonin deficit: on pineal calcification and melatonin excretion. Neuropsychopharmacology, (6):765-772
  2. Mahlberg R et al., Degree of pineal calcification (DOC) is associated with …, Sleep Med (2008)
  3. Luke J. Ph.D. Thesis. Guildord: University of Surrey; 1997. The Effect of Fluoride on the Physiology of the Pineal Gland.
  4. Rosales-Corral SA, Acuna-Castroviejo D, Coto-Montes A, Boga JA, Manchester LC, Fuentes-Broto L, Korkmaz A, Ma S, Tan DX, Reiter RJ. Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin. J Pineal Res. 2012;52:167–202
  5. He H, Dong W, Huang F. Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease. Curr Neuropharmacol. 2010;8:211–7
  6. Luke J. (2001). Fluoride deposition in the aged human pineal gland. Caries Res. 35(2):125-128
  7. Kunz D1, Schmitz S, Mahlberg R, Mohr A, Stöter C, Wolf KJ, Herrmann WM.A new concept for melatonin deficit: on pineal calcification and melatonin excretion.Neuropsychopharmacology. 1999 Dec;21(6):765-72.
  8. Rapoport SI: Blood-Brain Barrier in Physiology and Medicine. New York, Raven Press, 1976, p 77-78
  9. macchi MMB, Jeffrey N. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol 2004;25(3-4): 177-95
  10. National Research Council. (2006). Fluoride in Drinking Water: A Scientific Review of EPA’s Standards. National Academies Press, Washington D.C
  11. Mahlberg R, et al. (2009). Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients. Sleep Med. 10(4):439-45
  12. Haimov I LM, Zisapel N, Souroujon M, Nof D, Shiltner A, Herer P, Tzischinsky O, Lavie P. sleep disorders and melatonin rhythms in elderyly people. BMJ 1994;309(6948): 167
  13. Hajak G RA, Staedt J, Bandelow B, Huether G, Ruther E. Nocturnal plasma melatonin levels in patients suffering from chronic primary insomnia. J Pineal Res 1995; 19(3): 116-22
  14. National Research Council (US) and Institute of Medicine (US) Forum on Adolescence; Kipke MD, editor. Adolescent Development and the Biology of Puberty: Summary of a Workshop on New Research. Washington (DC): National Academies Press (US); 1999. Key Findings of Recent Studies
  15. Schlesinger ER, et al. (1956). Newburgh-Kingston caries  fluorine study. XIII. Pediatric findings after ten years. J Am Dent Assoc. 52(3):296-306
  16. Hankinson, Susan E et al. “Towards an integrated model for breast cancer etiology: the lifelong interplay of genes, lifestyle, and hormones.” Breast cancer research : BCR vol. 6,5 (2004): 213-8.
  17. Tina Kaczor. An Overview of Melatonin and Breast Cancer.February 2010 Vol. 2 Issue 2
  18. Haim, Abraham, and Abed E Zubidat. “Artificial light at night: melatonin as a mediator between the environment and epigenome.” Philosophical transactions of the Royal Society of London. Series B, Biological sciences vol. 370,1667 (2015): 20140121.
  19. Chinoy NJ, et al. (2004). Biochemical effects of sodium fluoride and arsenic trioxide toxicity and their reversal in the brain of mice. Fluoride 37: 80-87
  20. Chen, Xueping et al. “Oxidative stress in neurodegenerative diseases.” Neural regeneration research vol. 7,5 (2012): 376-85. doi:10.3969/j.issn.1673-5374.2012.05.009
  21. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, et al. Dementia prevention, intervention, and care. Lancet. 2017;390:2673–734.
  22. Song, J. Pineal gland dysfunction in Alzheimer’s disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis. Mol Neurodegeneration 14, 28 (2019)
Casey J Krol

Casey J Krol

The guy exposing the truth about fluoride, one great article at a time. Now if you’d like to support what I do or show thanks, click on the “Donate” button below. While if you have any questions, use the buttons below to send me a message (use IG for a faster response).

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